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Bone remodeling is carried out through the work of osteoclasts, which are bone cells that resorb bone and dissolve its minerals; and osteoblasts, which are bone cells that make the new bone matrix. Bones remodeling serves several functions.
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18 lip 2022 · Bone remodeling replaces old and damaged bone with new bone through a sequence of cellular events occurring on the same surface without any change in bone shape.
17 mar 2023 · The function of bone remodeling is to adjust the architecture to meet the changing needs of the body. Bone remodeling also helps to repair microdamage in the bone matrix, which prevents the accumulation of old bone. Additionally, bone remodeling aids in maintaining plasma calcium homeostasis.
6 kwi 2016 · The bone remodeling process is controlled by various local and systemic factors, and their expression and release, in a well organized manner. Calcitonin (CT), parathyroid hormone (PTH), vitamin D3 [1,25 (OH) 2 vitamin D 3] and estrogen are the major hormonal regulators of osteoclastic bone resorption.
The bone remodelling cycle replaces old and damaged bone and is a highly regulated, lifelong process essential for preserving bone integrity and maintaining mineral homeostasis. During the bone remodelling cycle, osteoclastic resorption is tightly coupled to osteoblastic bone formation.
18 lut 2022 · Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via a balance between bone formation by osteoblasts and resorption by osteoclasts.
Specifically discussed in detail are the cellular and molecular mechanisms of bone remodeling, including events that orchestrate the five sequential phases of bone remodeling: activation, resorption, reversal, formation, and termination.
