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  1. 3 maj 2019 · Variola virus (VARV), the etiological agent of smallpox, is a historical cause of immense morbidity and mortality that resulted in an estimated 300–500 million deaths in the twentieth century alone. However, in vitro and in vivo investigations with infectious...

  2. Variola Virus. Variola is a human-specific virus. Generally it can be readily distinguished from other orthopoxviruses capable of infecting man (vaccinia, cowpox, monkeypox) by the characteristic small white pocks produced on the chorioallantoic membrane of developing 12-to 15-day-old chick embryos and the ceiling temperature of growth. How ...

  3. Variola virus forms the characteristic pus-filled pustules and centrifugal rash dis-tribution in the infected patients while trans-mission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.

  4. Comparative genomics of 45 epidemiologically varied variola virus isolates from the past 30 years of the smallpox era indicate low sequence diversity, suggesting that there is probably little difference in the isolates' functional gene content.

  5. Aim of this study was to reconstruct the phylogeography of variola virus (VARV) in the XX century, using 47 VARV whole genome sequences available in public databases, through two different methods for ancestral character reconstruction: a frequently ...

  6. The vires spreads to different organs of the host and in this process causes tissue damage. Strains of a virus (e.g., variola major and variola minor) differ in their vimlence or ability to cause fatal disease.

  7. 28 maj 2024 · Variola virus forms the characteristic pus-filled pustules and centrifugal rash distribution in the infected patients while transmission occurs mainly through respiratory droplets during the early stage of infection. No antiviral drugs are approved for variola virus till date.

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