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22 lut 2023 · Initial: A single level should be drawn within the first 24-48 hours after the first dose. An earlier initial level may be helpful in ensuring therapeutic concentrations in certain clinical scenarios (i.e. critically ill patients, patients with high or low BMI, etc.)
In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
Compared to patients with trough levels ≤30 mg/L or no trough levels, patients with elevated levels had longer average duration of vancomycin therapy (6.0 days vs. 3.4 days vs. <1 days, p<.001) and higher maximum dose (1.7 g vs. 1.6 g vs. 1.3 g, p<.001).
2 sie 2024 · The optimal approach to vancomycin dosing and monitoring for invasive methicillin-resistant S. aureus (MRSA) infections is a subject of ongoing controversy and study. Challenges include how best to optimize clinical efficacy (particularly in the setting of emerging resistance) while minimizing toxicity (primarily nephrotoxicity) [ 6-9 ].
This vancomycin calculator uses pharmacokinetic population estimates, Bayesian modeling, and the Sawchuk-Zaske method to calculate a vancomycin dosing regimen for an adult patient. Vancomycin regimens can be calculated both empirically (without any prior doses) or using one or two vancomycin levels.
1 sie 2009 · Vancomycin dosages of 15–20 mg/kg (based on actual body weight) given every 8–12 h are required for most patients with normal renal function to achieve the suggested trough serum concentrations when the MIC is <1 mg/L.
