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In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is acceptable in a patient receiving every 8- or 12-hour dosing.
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
The risk of nephrotoxicity has been demonstrated to...
- Optimal Practice for Vancomycin Therapeutic Drug Monitoring ... - LWW
2 sie 2024 · Learn how to optimize vancomycin therapy for invasive gram-positive infections, including MRSA, based on guidelines and literature review. Find out how to monitor vancomycin serum concentrations and adjust dosing based on kidney function and pathogen susceptibility.
A pharmacokinetic calculator with Bayesian modeling to optimize vancomycin dosing for adult patients. Enter patient parameters, renal function, drug levels, and dosing history to calculate vancomycin clearance, volume of distribution, and trough levels.
Vancomycin AUC and trough concentrations should be less than 800 μg × h/mL over 24 hours and 15 μg/mL, respectively, to minimize acute kidney injury (evidence quality: A-II). All the recommendations for pediatrics are new for the updated guideline.
24 mar 2023 · Obtaining vancomycin serum trough concentrations allows healthcare professionals to evaluate the efficacy of the vancomycin dosing regimen and clearance of the drug by the individual patient. The target therapeutic serum trough concentration varies depending on the indication and typically ranges between 10 mcg/mL to 20 mcg/mL.
The risk of nephrotoxicity has been demonstrated to incrementally increase with greater exposure (as measured by trough or AUC 24), even within the therapeutic range (s). The risk of toxicity is considered to increase above an AUC 24 of 650 mg·h/L or a trough concentration of 15 mg/L.
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
