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23 wrz 2021 · Peak and trough levels indicate drug levels in an individual’s body. A peak is the highest level of a medication in the blood, while a trough level indicates the lowest concentration. Troughs of medication concentration occur after the drug has been broken down and metabolized by the body.
A trough level is drawn when the drug is at its lowest in the bloodstream, right before the next scheduled dose is given. Medications have a predicted reference range of normal values for peak and trough levels.
Trough concentrations can be measured to determine drug accumulation and to reduce the risk of toxicity. Trough samples must be interpreted in the context of the time after the dose when the sample was drawn.
A trough level can be pertinent when the concentration–effect relationship suggests that efficacy (or toxicity) of a drug is linked to the maintenance of blood concentrations above a predefined targeted concentration (glycopeptides, antiviral or antiretroviral drugs, for instance). From: Therapeutic Drug Monitoring, 2012
The trough levels are the most reliable measurement of drug elimination and more closely reflect the potential for drug accumulation in patients with renal failure. Knowing the potential a drug has for direct renal toxicity is important in patients with decreased renal function. Read more. View article. https://www.sciencedirect.
The trough level is the lowest concentration of a drug in the bloodstream before the next dose is administered. This measurement is crucial for understanding how well a drug is being absorbed and eliminated from the body, especially in relation to its therapeutic effects and potential toxicity.
