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EIA reactive, RPR non-reactive, TP-PA non-reactive The treponemal tests do not agree. This may be due to early infection where TP-PA has not yet developed, prior syphilis (treated or untreated), or potentially a false positive EIA.
15 wrz 2010 · Both sensitive and specific, new screening tests detect antitreponemal IgM and IgG antibodies by use of wild-type or recombinant T. pallidum antigens. However, these tests cannot distinguish between recent and remote or treated versus untreated infections.
T. pallidum subsp. pallidum is the causative organism for syphilis. Three morphologically identical subspecies of T. pallidum have been classified as follows: T. pallidum subsp. pallidum (syphilis) T. pallidum subsp. pertenue (yaws), and. T. pallidum subsp. endemicum (bejel).
9 lip 2018 · Confirmation of reactive results is performed with a treponemal test (eg, Treponema pallidum particle agglutination assay [TPPA]). While nontreponemal tests are inexpensive and useful for monitoring response to treatment, they require significant hands-on time by laboratory personnel.
25 mar 2022 · Unlike nontreponemal tests, treponemal syphilis tests look for antibodies which are specific to Treponema pallidum, so they can be used to confirm the screening test results. There are different treponemal tests available, including: Microhemagglutination assay for T. pallidum; T. pallidum particle agglutination; T. pallidum hemagglutination assay
Patients with discordant serology (e.g. EIA-reactive, RPR-non-reactive) present diagnostic and treatment challenges for clinicians, because these results may reflect either a false positive treponemal EIA, prior syphilis, or very early syphilis prior to development of a reactive RPR.
9 wrz 2024 · If a second treponemal test is positive (e.g., EIA reactive, RPR nonreactive, TP-PA reactive), persons with a history of previous treatment will require no further management unless sexual history indicates a reexposure.
