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  1. 12 gru 2023 · Ultimately, a key goal is for screening to encompass as many children as possible at risk for sepsis and trigger early treatment without increasing unnecessary broad-spectrum antibiotics and preventable hospitalizations.

  2. Pediatric sepsis is a common problem worldwide and is associated with significant morbidity and mortality. Best practice recommendations have been published by both the American College of Critical Care Medicine and the Surviving Sepsis Campaign to guide the recognition and treatment of pediatric sepsis.

  3. As reviewed below, therapeutic approaches to sepsis remain predominantly supportive but are founded on fundamental physiologic principles that largely define critical care medicine and entail four important goals: initial resuscitation, pathogen eradication, maintenance of oxygen delivery, and more specifically directed modifiers of the inflamma...

  4. 9 maj 2023 · Early diagnosis and timely intervention with antibiotics, fluid resuscitation, and vasoactive medications are the most important interventions in sepsis. The implementation of protocols, resource-adjusted sepsis bundles, and advanced technologies will have an impact on reducing sepsis mortality.

  5. 19 wrz 2024 · Progression to organ failure and shock is often very rapid, so early recognition and treatment is crucial. Empirical broad-spectrum antibiotic therapy (based on the most probable pathogens) should be administered as soon as possible, and always within the first hour following recognition of sepsis.

  6. 1 maj 2020 · Topics: surviving sepsis campaign. In July 2019, the American Academy of Pediatrics endorsed the following publication: Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Pediatr Crit Care Med. 2020;21 (2):e52–e106.

  7. This clinical pathway was developed by a consensus group of Johns Hopkins All Children’s Hospital (JHACH) physicians, advanced practice providers, nurses and pharmacists to standardize the recognition and management of children presenting with clinical signs of sepsis.

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