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Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
The elimination half-life (t1/2) is the time required for the amount of drug in the body to decrease by half (eqn [5]). The half-life is independent of the dose of the drug administered and is a useful indicator of how fast a drug is removed from the body.
Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half-life is a hybrid parameter controlled by plasma ….
The elimination half-life (T1/2) refers to the time it takes for the body to reduce the plasma concentration or amount of a drug by 50 percent. It is determined by both clearance and volume of distribution.
20 cze 2023 · Half-life in the context of medical science typically refers to the elimination half-life. The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body.
The elimination half-life (t 1/2) is the time required for the amount of drug in the body to decrease by half (Eq. 5). For drugs that exhibit linear PK, the half-life is independent of the dose of the drug administered and is a useful indicator of how fast a drug is removed from the body.
The half-lives, including the terminal half-life, related to the exponential functions in the equation describing multicompartment kinetics following intravenous drug administration. Each of the disposition half-lives reflect all of the rate constants in a multicompartment model.
