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30 mar 2022 · Novel strategies that consider patient-specific variables, including markers of inflammation, may result in an individualized approach to corticosteroid use in the treatment of patients with community-acquired pneumonia.
Among children with bacterial pneumonia, corticosteroids reduced early clinical failure rates (defined as for adults, RR 0.41, 95% CI 0.24 to 0.70; high-quality evidence) based on two small, clinically heterogeneous trials, and reduced time to clinical cure.
Summary: According to the current evidence, there are no data to support the well tolerated use of systemic steroids as a standard of care in pneumonia, neither in mild-to-moderate and severe, nor in bacterial and viral infection.
In CHEST, Saleem et al1 present a systematic review and meta-analysis that evaluate the effectiveness of corticosteroids for pneumonia.
5 wrz 2015 · In a randomised controlled trial (RCT), treatment with oral prednisone for 7 days shortened time to clinical stability, as defined by stabilisation of vital signs and symptoms, and hastened hospital discharge in patients with community-acquired pneumonia (CAP). 1
21 mar 2023 · In a trial involving 120 critically ill patients with community-acquired pneumonia and a C-reactive protein level of more than 15 mg per deciliter, treatment with methylprednisolone reduced a ...
Guidelines. The new ATS/IDSA guidelines advise against adjunctive corticosteroid treatment of CAP or influenza pneumonia except in patients who have other indications for their use, such as asthma, COPD, or an autoimmune disease.
