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18 sie 2023 · COVID-19 is a systemic viral illness based on its involvement in multiple major organ systems. Patients with advanced age and comorbid conditions such as obesity, diabetes mellitus, chronic lung disease, cardiovascular disease, chronic kidney disease, chronic liver disease, and neoplastic conditions are at risk of developing severe COVID-19 and ...
9 lut 2021 · Here, we introduce recent knowledge of time course changes in viral titers, delayed virus clearance, and persistent systemic inflammation in patients with severe COVID-19.
11 lis 2021 · Systemic inflammation reflects an excessive activation of circulating leukocytes, particularly in response to viremia. These two types of clinical inflammation can co-exist. They result from a failure of cell-intrinsic immunity to control the intracellular virus in leukocytes, or, more commonly, in other cells.
14 lip 2022 · Although during viral infections IFNs primarily exhibit an antiviral function, they also shape inflammatory responses by their immunomodulatory effects on the activation status of immune cells. Analysis of the systemic IFN signatures of hospitalized COVID-19 patients revealed that the cell-specific responses were associated with distinct IFNs ...
1 wrz 2021 · Our results reveal distinct responses between nasopharyngeal and systemic immunity, with a strong impact on the nasopharyngeal cytokine response and microbiome in severe COVID-19. These results...
14 gru 2022 · Our data indicate that in some patients SARS-CoV-2 can cause systemic infection and persist in the body for months.
22 gru 2021 · Here, to examine the differences between children and adults in their response to SARS-CoV-2 infection, we analysed paediatric and adult patients with COVID-19 as well as healthy control ...
