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18 paź 2024 · Steroids play an integral part in maintaining the structural integrity and functionality of cell membranes. Cholesterol, a predominant steroid in animal cells, is interspersed within the phospholipid bilayer, where it acts as a modulator of membrane fluidity.
Steroid–membrane interactions are relevant to multiple steps of steroid biosynthesis and action, as steroids are known to interact with neurotransmitter or membrane steroid receptors, and steroids must cross lipid membranes to exert their physiological functions.
14 sie 2018 · Steroids have various functions in cells and are involved in numerous metabolic pathways. Certain steroid compounds modulate the structure of biological membranes, typical examples including cholesterol in animals, β-sitosterol in plants, and ergosterol in fungi.
Even small differences in the substituents on the steroid core can result in significant changes in steroid-membrane interactions. Furthermore, steroid-induced changes in phospholipid bilayer properties are often dependent on steroid concentration and lipid composition.
1 lip 1999 · Recent studies suggest that steroid hormones use receptors on cellular membranes both to gain access to the intracellular compartment and to modulate cellular functions. These interactions with cell-surface receptors have important physiological consequences.
1 cze 2019 · Steroid hormones move freely into cells to activate intracellular nuclear receptors that function as multi-domain ligand-dependent transcriptional regulators in the cell nucleus. Activated nuclear receptors modify expression of hundreds to thousands of specific target genes in the genome.
Most people think of steroid signaling, it is through their nuclear effects on gene transcription (the predominant signaling effect). Signaling at the cell membrane is an emerging area of interest. We will present steroid signaling at the cell nucleus in four figures with their associated captions.
