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11 paź 2024 · Somatic mutations can cause early- or late-onset rheumatic monogenic diseases but also contribute to the pathogenesis of complex inflammatory and immune-mediated diseases, affect disease...
- Targeting of somatic hypermutation | Nature Reviews Immunology
Somatic hypermutation (SHM) introduces mutations in the...
- Targeting of somatic hypermutation | Nature Reviews Immunology
Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes).
Somatic hypermutation (SHM) is the incorporation of point mutations within the immunoglobulin V-region genes, which serve as the basis for affinity maturation and effective immune responses. The process is initiated by antigen stimulation, occurs in the dark zone of germinal centres, and requires functional AID [49].
Once antigen enters the system, it stimulates a somatic mutational mechanism that generates antibodies of higher affinity and selects for the expression of those antibodies to produce a more effective immune response.
A somatic mutation can drastically alter the metabolism of the cells in which it resides. Because cancer begins with the disruption of metabolism in a single cell, somatic mutations make significant contributions to the development and progression of many cancers. As a cancer progresses, the malignant cells often accumulate gene mutations and ...
1 sie 2006 · Somatic hypermutation (SHM) introduces mutations in the variable region of immunoglobulin genes, to generate high-affinity B-cell antigen receptors.
7 cze 2024 · Here, we examined somatic mutations in CD4 + and CD8 + T cells from 90 patients with hematological and immunological disorders and used T cell receptor (TCR) and single-cell sequencing to link mutations with T cell expansions and phenotypes.
