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11 sie 2024 · Mechanism of Action. Methylprednisolone and its derivatives, methylprednisolone acetate succinate and methylprednisolone sodium, are intermediate-acting synthetic glucocorticoids. They are typically prescribed as anti-inflammatory or immunosuppressive agents.
Solu-Medrol is the only derivative of methylprednisolone that is approved for intravenous infusion, as the sterile powder is soluble in water and can be mixed with a diluent. Strengths vary from 40 mg to 2 g.
17 lut 2020 · Methylprednisolone is a corticosteroid that regulates gene expression and decreases inflammation. It is used to treat various diseases and conditions, and the dosage depends on the form, route, and indication.
Methylprednisolone’s mechanism of action is through its binding to intracellular glucocorticoid receptor. Upon binding, this complex translocates to the nucleus, where it interacts with specific DNA sequences, resulting in suppression of downstream target genes.
28 lut 2023 · Anti-inflammatory actions relieves fever, acute thyroid pain, and swelling. May reduce orbital edema in endocrine exophthalmos (thyroid ophthalmopathy). Usually reserved for palliative therapy in severely ill patients unresponsive to salicylates and thyroid hormones.
Methylprednisolone sodium succinate has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity.
Learn about the synthetic glucocorticoid MPSS, also known as Solu-medrol, and its mechanisms of action in traumatic spinal cord injury. Find out the preclinical and clinical data, dosage, and guidelines for MPSS therapy.
