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Summary: Ovarian hyperstimulation syndrome (OHSS) is a complication of fertility treatment, which uses pharmacological ovarian stimulation to increase the number of oocytes and therefore embryos available during assisted reproductive technology (ART).
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This guideline aims to review the literature and provide evidence-based advice to help clinicians diagnose and manage patients with OHSS. Prevention of OHSS is outside the scope of this guideline and is covered by guidance from the British Fertility Society.4 2. Introduction and background epidemiology
Key points. OHSS is a potentially serious complication of fertility treatment, particularly of IVF. It can range from mild to severe. Mild OHSS is common and usually gets better with time. More severe cases require specialist care and hospital admission. It is important to make contact with your fertility unit if you develop symptoms of OHSS.
RCOG Green-top Guideline No. 5 entitled The Management of Ovarian Hyperstimulation Syndrome; published February 2016. 1.2. Objective The objective of the guideline is to: Provide evidence-based guidance for gynaecology staff on the assessment and management of women with ovarian hyperstimulation syndrome
RCOG Green-top Guideline No. 5 10 of 22 © Royal College of Obstetricians and Gynaecologists Gynaecology and emergency departments in acute hospitals should develop evidence-based local protocols covering the assessment and management of women presenting with suspected OHSS.
Selected cases mild and moderate OHSS can be monitored without hospital admission with the provision of regular visits for clinical and haematological monitoring. Women admitted with severe (OHSS) require intensive monitoring and the care of a specialised team.
The Royal College of Obstetricians and Gynaecologists' (RCOG) Green Top Guidelines (2016) explains OHSS to be “the occurrence of ovarian enlargement with the local and systemic effect of proinflammatory mediators, including increased vascular permeability and prothrombotic effect”.
