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23 lis 2020 · Three randomised, double-blind trials, which reported superiority of amantadine (200 mg/day) over placebo in reducing multiple sclerosis fatigue, used visual analogue scales, daily diary rating, and multiple sclerosis-specific fatigue scales as their outcome measures.
Multiple randomized, placebo-controlled, patient-blind, or double-blind trials with sample sizes ranging between 21 and 121 participants tested the efficacy of modafinil 200 to 400 mg/day in reducing the MFIS or FSS scores. All reported that modafinil was not superior to placebo in improving MS-related fatigue.
10 lip 2024 · The data indicates that modafinil confers a therapeutic benefit when treating fatigue in patients with MS and improves overall quality of life; however, there is a risk of precipitating adverse events. Ultimately, higher quality of evidence may be required to better inform clinical management.
Conclusions: These data suggest that 200 mg/day modafinil significantly improves fatigue and is well tolerated in patients with MS. Methods: Patients aged 18–65 years with a diagnosis of MS, a stable disability level ≤6 on the Kurtzke extended disability status scale (EDSS), and a mean score >4 on the fatigue severity scale (FSS) were ...
The recommended dosage of Provigil is 200 mg per day, providing an optimal balance between effectiveness and minimizing potential side effects. Its carefully calibrated dosage ensures that you can experience the benefits without compromising your well-being.
1 sty 2022 · Some studies have shown that modafinil at a dose of 200 mg/day may be beneficial in MS fatigue (Möller et al., 2011) but a more recent study showed no effect in comparison with placebo (Ford-Johnson et al., 2016).
23 lip 2024 · Treatment with modafinil, a stimulant approved in the U.S. for treating certain sleep-related disorders, significantly reduced fatigue and improved overall quality of life when used in clinical...
