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2 paź 2024 · PHAX (Phosphorylated Adaptor For RNA Export) is a Protein Coding gene. Diseases associated with PHAX include Intellectual Developmental Disorder, Autosomal Dominant 10 and Leukodystrophy, Demyelinating, Adult-Onset, Autosomal Dominant .
14 kwi 2000 · We identify PHAX (phosphorylated adaptor for RNA export) as the additonal factor required for U snRNA export complex assembly in vitro. In vivo, PHAX is required for U snRNA export but not for CRM1-mediated export in general.
Phosphorylated adapter RNA export protein is a protein that in humans is encoded by the PHAX gene. [5] [6]
1 sty 2020 · PHAX (phosphorylated adaptor for RNA export) promotes nuclear export of short transcripts of RNA polymerase II such as spliceosomal U snRNA precursors, as well as intranuclear transport of small nucleolar RNAs (snoRNAs). However, it remains unknown whether PHAX has other critical functions.
17 cze 2024 · PHAX RNA-binding domain mediates auxiliary RNA contracts with small nuclear and mall nucleolar RNA substrates. PHAX and CRM1 have roles in transporting U3 snoRNA to nucleoli. Enables mRNA cap binding complex binding activity. Involved in RNA stabilization. Located in centrosome and nucleoplasm.
PHAX is a gene that encodes a protein involved in RNA export. It has low tissue and regional specificity, and is ubiquitously expressed in the nucleoplasm of various cell types.
