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HIV is the greatest escapist. HIV-1 Strategies to counteract host immunity. Adaptive immunity. Intrinsic immunity. HUGE GENETIC DIVERSITY. Population level. Individual level. Deep sequencing. Sanger sequencing. Balance between mutation rate, drift and selection. High replication rate: 109-12 new virions/day. Error-prone polymerase:
Breakthroughs in the prevention of HIV important to public health include male medical circumcision, antiretrovirals to prevent mother-to-child transmission, antiretroviral therapy in people with HIV to prevent transmission, and antiretrovirals for pre-exposure prophylaxis.
27 lip 2024 · This clinical reference focuses primarily on HIV-1 and is designed to review the pathophysiology, clinical manifestations, and recommended treatment options for patients with HIV, providing clinicians with concise and up-to-date guidance for managing HIV.
1 sty 2023 · Extraordinary efforts led to important advances in virology, immunology and pathophysiology, and therapeutics that changed the paradigm of HIV management.
6 cze 2013 · More than 80% of HIV-related deaths occurred because of infectious diseases. This is evident as research demonstrates how viral and host factors contribute to the pathogenesis of HIV...
19 lip 2014 · Breakthroughs in the prevention of HIV important to public health include male medical circumcision, antiretrovirals to prevent mother-to-child transmission, antiretroviral therapy in people with HIV to prevent transmission, and antiretrovirals for pre-exposure prophylaxis.
• ART started at Fiebig I (HIV RNA+, p24 Ag-, Ab-) for ≥ 96 w. • VL <50 c/mL ≥48 w & CD4 >400 cells. • Resume ART if two VL >1000 c/ml or two CD4 <350 cells. • TI for 24 w. VL every 3-7 days. Hypothesis. • At least 30% of individuals will have delayed time to VL rebound (VL<50 at 24 w). • Proceed to stage 2 if ≥ 1 person has
