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Unlike proteins, nucleic acids contained no sulfur. Complete hydrolysis of chromosomal nucleic acids gave inorganic phosphate, 2-deoxyribose (a previously unknown sugar) and four different heterocyclic bases (shown in the following diagram). To reflect the unusual sugar component, chromosomal nucleic acids are called deoxyribonucleic acids ...
- 11.1: Structure and Function
The nucleic acids, DNA and RNA, may be thought of as the...
- 11.1: Structure and Function
Nucleic acid hydrolysis. The nucleic acid chain can be cleaved either enzymatically or non-enzymatically. A 2'-OH group is required for the alkaline hydrolysis of a polynucleotide, as its first step is the transfer of the bond from C5' of the following nucleotide to C2' of the same nucleotide.
This role is naturally carried out by nucleases, which catalyse the cleavage of DNA either by hydrolysis of the phosphate diester bond (with varying degrees of sequence specificity) or by catalysing elimination of phosphate (and destroying one of the nucleotide units).
This role is naturally carried out by nucleases, which catalyse the cleavage of DNA either by hydrolysis of the phosphate diester bond (with varying degrees of sequence specificity) or by catalysing elimination of phos phate (and destroying one of the nucleotide units).
Complete hydrolysis of nucleic acids (see Section 3.4) by chemical or enzymatic means liberates the nucleic acid “building blocks”: phosphate, sugar (ribose or deoxyribose), and bases, in a 1:1:1 ratio.
23 sie 2021 · The nucleic acids, DNA and RNA, may be thought of as the information molecules of the cell. In this section, we will examine the structures of DNA and RNA, and how these structures are related to the functions these molecules perform.
30 maj 2018 · The hydrolysis of PPi occurs after the formation of the phosphodiester bond and ensures that the DNA synthesis reaction is energetically favorable without the need for additional enzymes. Also, we observe that DNA synthesis is a two Mg 2+ ion assisted stepwise associative S N 2 reaction.
