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Learn about the structure, function, and regulation of nicotinic receptors, which respond to acetylcholine and nicotine. Find out how they are involved in muscle contraction, nerve signaling, immune system, and drug addiction.
Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins from a...
Learn about nicotinic receptors, a family of ligand-gated ion channels activated by acetylcholine and nicotine. Find chapters and articles on their structure, function, subunit composition, and pharmacology.
4 kwi 2018 · The nicotinic acetylcholine receptor (nAChR) is a typical ion channel type receptor. nAChR agonists such as nicotine evoke rapid excitatory responses in order of milliseconds.
Nicotine binds to neuronal nicotinic acetylcholine receptors (nAChRs), which come in a diverse collection of subtypes. The nAChRs that contain the α4 and β2 subunits, often in combination with the α6 subunit, are particularly important for nicotine’s ability to increase midbrain dopamine neuron firing rates and phasic burst firing.
Nicotinic receptor subunits are part of a large superfamily of ligand-gated channels. Nicotinic receptors on neurons, such as those originating in the CNS or neural crest, show ligand specificities distinct from the nicotinic receptor in the neuromuscular junction.
5 cze 2009 · Nicotine exerts its biological effects through nicotinic acetylcholine receptors (nAChRs). nAChRs are prototypical members of the ligand-gated ion channel superfamily of neurotransmitter...
