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Learn about the structure, function, and regulation of nicotinic receptors, which respond to acetylcholine and nicotine. Find out how they are involved in muscle contraction, nerve signaling, immune system, and drug addiction.
Receptory nikotynowe N – białka receptorowe mające strukturę pentameru, zbudowanego z różnych kombinacji genetycznie odmiennych jednostek α (1-10), β (1-4), γ, δ i ε.
Nicotine binds to neuronal nicotinic acetylcholine receptors (nAChRs), which come in a diverse collection of subtypes. The nAChRs that contain the α4 and β2 subunits, often in combination with the α6 subunit, are particularly important for nicotine’s ability to increase midbrain dopamine neuron firing rates and phasic burst firing.
Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins...
Nicotinic receptor subunits are part of a large superfamily of ligand-gated channels. Nicotinic receptors on neurons, such as those originating in the CNS or neural crest, show ligand specificities distinct from the nicotinic receptor in the neuromuscular junction.
5 cze 2009 · Nicotine exerts its biological effects through nicotinic acetylcholine receptors (nAChRs). nAChRs are prototypical members of the ligand-gated ion channel superfamily of neurotransmitter...
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels and can be divided into two groups: muscle receptors, which are found at the skeletal neuromuscular junction where they mediate neuromuscular transmission, and neuronal receptors, which are found throughout the peripheral and c ….
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powiązane z: nicotinic receptorSanta Cruz Biotechnology, Inc. is a leader in developing products for biomedical research. Monoclonal antibody conjugates available for direct detection. Ask us about a free sample.
