Search results
1 paź 2018 · In this review, both the physiology of insulin action and the pathophysiology of insulin resistance are described, focusing on three key insulin target tissues: skeletal muscle, liver, and white adipose tissue.
Understanding insulin resistance, in turn, requires knowledge of normal insulin action. In this review, both the physiology of insulin action and the pathophysiology of insulin resistance are described, focusing on three key insulin target tissues: skeletal muscle, liver, and white adipose tissue.
Because extrahepatic control of HGP is quantitatively significant, the purest experimental readouts of direct hepatocellular insulin action are insulin-stimulated glycogen synthesis, insulin-regulated transcripts, and phosphorylation events within the insulin signaling cascade.
Summary. Insulin and insulin-like growth factor signalling integrates metabolism, growth, reproduction, and lifespan with environmental signals. Dysregulated insulin signalling causes insulin resistance, which includes any state of diminished cellular or systemic insulin action.
1 paź 2021 · At the cellular level, insulin initiates action by binding to its membrane receptor. The insulin receptor (InsR) is encoded by a 150-kb gene composed of 22 exons on human chromosome 19p13.3-p13.2.
6 lip 2022 · In this review, the mechanism of insulin action and IR are first described to promote the development of new therapeutic strategies.
4 paź 2017 · The three major biochemical steps in insulin signalling are: tyrosine phosphorylation of the receptor and its direct substrates; activation of the lipid kinase, PI3K; and activation of multiple...
