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Because of its dramatic effect on blood vessels, L-Arginine can cause headaches as a side effect in some individuals. L-Arginine opens the blood vessels throughout the body, including those within the brain.
27 mar 2023 · Key outcome measures include frequency of migraines attacks and intensity of headache pain. Additional exploratory outcome measures include changes in photosensitivity, retinal vascular diameter, and blood biomarkers of vascular tone.
27 mar 2023 · The primary objective of the LARGE trial is to evaluate the effectiveness of oral supplementation of L-arginine, AGE or the combined treatment of oral L-arginine and AGE, in reducing the severity and frequency of migraine attacks in chronic frequent episodic migraines in adults.
11 lis 2022 · The primary aim of the L-Arginine and Aged Garlic Extract (LARGE) trial is to investigate whether oral treatment with dietary nutraceuticals, L-arginine and aged garlic extract (AGE), both systemic vasodilatory agents, will alleviate migraine frequency, duration and severity in adults with chronic frequent episodic migraines.
Thus, this prospective study aimed to measure the serum concentrations of the NO substrate L-arginine, the NO synthase inhibitor asymmetric dimethylarginine (ADMA), and the L-arginine transport regulator symmetric dimethylarginine (SDMA) in migraine patients in a headache-free period.
27 mar 2023 · Accumulating evidence suggests that cerebral arteries dilate during migraine, causing distal microvessels to constrict, which could activate nociceptors and cause onset of headache pain. If so, preventing or attenuating chronic microvascular constriction, and promoting a dilatory phenotype, may reduce frequency and/or severity of migraines.
23 lip 2021 · We propose that the putative beneficial effect of l-arginine and AGE in this patient is because of the well-established systemic vasodilatory effects of l-arginine and aged garlic extract.
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