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Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
Interleukina 1 (IL-1) – zbiorcza nazwa, którą określa się cytokiny o kluczowym znaczeniu dla procesu zapalnego i szerokim spektrum działania. Cytokina ta jest wydzielana w odpowiedzi na różne antygeny pochodzenia wirusowego, bakteryjnego i grzybiczego.
Interleukin-1 (IL-1) is a cytokine which governs inflammatory responses by binding IL-1 α and β agonist with its receptor IL-1R (Vigers et al., 1997). IL-1β is synthesized by inflamasome-mediated caspase action (Bent et al., 2018) and enhances the immune reaction (Dinarello, 2014).
1 sie 2011 · The cytokine interleukin-1β (IL-1β) is a key mediator of the inflammatory response. Essential for the host-response and resistance to pathogens, it also exacerbates damage during chronic disease and acute tissue injury.
In cells that express the coreceptor, termed IL-18 receptor beta chain (IL-18Rβ, now IL-1R7), a high-affinity complex is formed, which then signals. The complex of IL-18 with the IL-1R5 and IL-1R7 chains is similar to that formed by other members of the IL-1 family with the coreceptor, IL-1R3.
18 sty 2010 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, their regulation...
Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease.
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