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Using state-of-the-art machine learning methods, we identified 12 major cardiac cell types and 75 different cell states. Cell states defined by sc/snRNA-seq data were mapped in spatial transcriptomics data from the eight regions using cell2location.
Using single cell technologies, we profiled the transcriptome of 486,134 cells and nuclei from six anatomical cardiac regions. Given the complexity of these data, we integrated them using state-of-the-art machine learning methods.
24 wrz 2020 · Nature - Single-cell and single-nucleus RNA sequencing are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease.
13 mar 2024 · These detailed findings into the cellular social interactions and specialization of cardiac cell types constructing and remodelling the human heart offer new insights into structural heart...
Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes and fibroblasts, and reveal distinct atrial and ventricular subsets of cells with diverse developmental origins and specialized properties.
Cells of the adult human heart. From Litviňuková et al: Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require a deeper understanding of the molecular processes involved in the healthy heart.
24 wrz 2020 · Now a team of scientists has created the first atlas of human heart cells, a collection of maps showing nearly half a million heart cells and identifying the role of each in the heart's...
