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6 paź 2016 · Although controversial, high folate status achieved through folate fortification or supplementation may increase the risk of certain chronic diseases among certain individuals, possibly by interfering with the homeostasis of one-carbon metabolism.
- Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate ...
Several studies sought to determine the relationship between...
- The Concept of Folic Acid in Health and Disease - PMC
Folates have a pterine core structure and high metabolic...
- Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate ...
Several studies sought to determine the relationship between high folate intake, chronic disease risk, and overall mortality. A systematic review by Colapinto et al. observed a negative association between high folate levels and adverse health outcomes.
27 lis 2019 · Among hypertensive adults, both low and high folate were associated with an elevated risk of dying from cardiovascular diseases compared with adults with moderate serum folate concentration.
18 cze 2021 · Folates have a pterine core structure and high metabolic activity due to their ability to accept electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential one-carbon pathways donating methyl-groups to choline phospholipids, creatine, epinephrine, DNA.
12 maj 2023 · Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations.
15 wrz 2016 · Lower folate levels, but not restricted to folate deficiency, are linked with higher rates of all-cause, CVD and cancer mortality. Adverse effects of excess folate as well as age and gender differences on mortality need further investigation.
1 sty 2002 · It is increasingly recognized that folates may play a role in the prevention of cardiovascular disease. Over the last few years, several studies have reported beneficial effects of folates on endothelial function, a surrogate end point for cardiovascular risk.
