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Bladder - Dysplasia; preneoplastic urothelial lesion that consists of cytological and architectural atypia which does not meet the criteria of a urothelial carcinoma in situ
Secondary dysplasia is classified as dysplasia identified in the setting of known neoplasia of the bladder, either current or prior. In either presentation, the patient is currently undergoing screening to assess current symptoms or monitoring of a precedent high-grade lesion.
The main differential diagnosis of urothelial dysplasia includes flat urothelial lesions with atypia, mainly flat (simple) urothelial hyperplasia, reactive urothelial atypia, urothelial atypia of unknown significance, and urothelial carcinoma in situ (high-grade intraurothelial neoplasia).
25 kwi 2022 · Dysplasia and CIS represent a continuum of flat lesions presenting features that may appear conflicting, including examples that are hyperplastic (as above), those that are low grade...
Results: Of the 37 cases with dysplasia, 10 (27%) had high-grade dysplasia (HGD) and the remaining showed low-grade dysplasia (LGD). All 4 cases of adenocarcinoma had some gross abnormalities (such as porcelain gallbladder, or ruptured, thickened, and roughened walls, or a granular mucosa).
12 paź 2022 · Key updates and recommendations on flat urothelial lesions. “Flat Urothelial Hyperplasia” is Recommended be Called “Atypical Urothelial Proliferation-Flat”. Urothelial dysplasia is a rare diagnosis with significant interobserver variability.
1 gru 2022 · In contrast, primary noninvasive glandular lesions are extremely rare and follow patterns in the gastrointestinal tract of low-grade and high-grade dysplasia. They occur in the setting of chronic irritation and intestinal metaplasia.
