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21 gru 2021 · Due to multiple factors, older patients tend to have a poorer prognosis than younger patients. "For a younger patient, median survival is probably in the 15- to 20-month range. For an older patient, the median survival rates are probably in the nine- to 12-month range," says Dr. Vora.
Current management includes surgery, radiation therapy (RT) and chemotherapy; however, survival is significantly worse than that observed in younger patients and the optimal treatment in terms of efficacy and safety remains a matter of debate.
16 mar 2017 · Glioblastoma is associated with a poor prognosis in the elderly. Survival has been shown to increase among patients 70 years of age or younger when temozolomide chemotherapy is added to...
31 sty 2022 · Glioblastoma (GBM) is the most common primary malignant intracranial tumor and the median age at diagnosis is 65 years. However, elderly patients are usually excluded from clinical studies and age is considered as an independent negative prognostic factor for patients with GBM.
Elderly people with GBM show dismal prognosis (about 6 months) and limited response to treatments. The reasons are many, and not entirely known. First, age is an independent negative prognostic factor, probably due to more aggressive tumour biology in the elderly population.
1 maj 2024 · High grade gliomas are the most common primary aggressive brain tumours with a very poor prognosis and a median survival of less than 2 years. The standard management protocol of newly diagnosed glioblastoma patients involves surgery followed by radiotherapy, chemotherapy in the form of temozolomide and further adjuvant temozolomide.
Despite standard of care with surgery, radiation, and chemotherapy, prognosis still remains poor with median overall survival (OS) of 15 months and only approximately 9 months for older patients . Age and ... Minniti G., Lombardi G., Paolini S. Glioblastoma in Elderly Patients: Current Management and Future Perspectives. Cancers. 2019;11:336 ...
