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The Hartford Nomogram method utilizes high-dose, once daily dosing to optimize the peak/MIC ratio in most clinical situations by administering a dose of 7mg/kg of either gentamicin or tobramycin. The Urban & Craig Nomogram is another method of extended-interval therapy utilizing 5 mg/kg of gentamicin or tobramycin in patients without renal ...
4 sie 2015 · Pre-dose (trough) gentamicin levels should be checked after 24 hours and then twice weekly (target <1mg/L). Peak gentamicin levels, taken one hour after administration, can also be measured (target 3–5mg/L).
9 maj 2022 · Patients who require treatment with gentamicin often require monitoring, which includes peak and trough levels. Peak levels are typically evaluated 30 minutes after completion of the infusion....
2.16.4. When gentamicin is indicated as adjunctive therapy in infective endocarditis use 3mg/kg. This should be informed by microbiology findings and advice. 2.17. Monitoring 2.17.1. Serum trough levels for monitoring should be TAKEN AT Least 18 HOURS AFTER THE PREVIOUS DOSE which should be between 0 and 6 hours before the due dose 2.17.2.
Guide for Drug Level Monitoring of Commonly Used Medications. “Trough”. Also referred to as “level” should always be before a dose (trough) even if provider does not specify. Within 30 minutes before 3rd or 4th dose (pediatrics: 3rd dose) Trough: < 8 mg/L.
10 kwi 2023 · It is recommended to avoid prolonged peak plasma concentrations of gentamicin of more than 12 mcg/mL, and trough concentrations of more than 2 mcg/mL. Renal function should be evaluated twice-weekly in patients without previous renal disease through serum creatinine and blood urea nitrogen.
27 cze 2022 · For neonates, peak concentrations of 5–12 mg/L and trough concentration of < 0.5–2 mg/L have been proposed based on adult data . Yet, studies addressing target attainment and its association with clinical cure are lacking.
