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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
First pass metabolism describes the metabolism of a drug molecules before it reaches the systemic circulation and can also be referred to as pre-systemic metabolism. Although it is possible via other routes of administration, it is predominant in drugs administered orally.
A workaround to the first-pass effect is to administer medication using alternate routes to the GI tract. Examples of alternative routes that avoid the first-pass effect include transdermal, nasal, inhalation, injection, or intravenous administration of medication.
Before an orally absorbed drug reaches systemic circulation, it must first pass through the intestine, and then the liver where drug metabolism known as pre-systemic metabolism may occur. This is known more commonly as the first-pass effect.
21 lip 2023 · The first pass effect is a crucial aspect of drug metabolism and bioavailability. Understanding its mechanism, factors influencing it, and its implications for drug therapy can guide healthcare professionals in optimizing drug dosing and selection to ensure optimal therapeutic outcomes.
