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1. www.ncbi.nlm.nih.gov › pmc › articlesOverview: How Is Alcohol Metabolized by the Body? - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   The rate of the rise of BAC is influenced by how quickly alcohol is emptied from the stomach and the extent of metabolism during this first pass through the stomach and liver (i.e., first-pass metabolism [FPM]).

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     Open in a Separate Window - Overview: How Is Alcohol...

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     NOTE: The ADH1B and ADH1C genes have several variants with...

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     Figure 2 - Overview: How Is Alcohol Metabolized by the Body?...

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     Metabolism of ethanol through alcohol dehydrogenase (ADH)...

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     PubMed - Overview: How Is Alcohol Metabolized by the Body? -...

2. en.wikipedia.org › wiki › First_pass_effectFirst pass effect - Wikipedia

   en.wikipedia.org › wiki › First_pass_effect

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   The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.

3. www.ncbi.nlm.nih.gov › pmc › articlesALCOHOL METABOLISM - PMC - National Center for Biotechnology...

   www.ncbi.nlm.nih.gov › pmc › articles

   First pass metabolism of alcohol occurs in the stomach and is decreased in alcoholics. Liver alcohol dehydrogenase is the major enzyme system for metabolizing alcohol; this requires the cofactor NAD and the products produced are acetaldehyde and NADH.

4. wires.onlinelibrary.wiley.com › doi › 10Alcohol, its absorption, distribution, metabolism, and excretion...

   wires.onlinelibrary.wiley.com › doi › 10

   20 maj 2019 · First-pass metabolism. This refers to disposal (metabolism) of some fraction of the dose of an administered drug before it reaches the systemic circulation. For an orally administered drug, this presystemic metabolism occurs by enzymes located in the gut and/or liver.

5. pubmed.ncbi.nlm.nih.gov › 23101976Alcohol metabolism - PubMed

   pubmed.ncbi.nlm.nih.gov › 23101976

   This article describes the pathways and factors that modulate blood alcohol levels and metabolism and describes how the body disposes of alcohol. The various factors that play a role in the distribution of alcohol in the body, influence the absorption of alcohol, and contribute to first-pass metabol ….

6. www.ncbi.nlm.nih.gov › pmc › articlesAlcohol Metabolizing Enzymes, Microsomal Ethanol Oxidizing System...

   www.ncbi.nlm.nih.gov › pmc › articles

   4 mar 2020 · The class IV ADH (µ-ADH, for the m ucosal isozyme or σ-ADH, for the s tomach isoenzyme) has been found in the esophagus and stomach and is responsible for alcohol first pass metabolism . Among ADHs, σ-ADH has the highest Vmax and is very active towards retinol.

7. www.liver.theclinics.com › article › S1089-3261(12)00085-2Alcohol Metabolism - Clinics in Liver Disease

   www.liver.theclinics.com › article › S1089-3261(12)00085-2

   First-pass metabolism of alcohol occurs in the stomach and is decreased in alcoholics. Liver alcohol dehydrogenase is the major enzyme system for metabolizing alcohol; this requires the cofactor nicotinamide adenine dinucleotide (NAD) and the products produced are acetaldehyde and reduced NAD (NADH).