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The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism at a specific location in the body which leads to a reduction in the concentration of the active drug before it reaches the site of action or systemic circulation.
21 lut 2023 · Efek lintas pertama, juga dikenal sebagai metabolisme atau eliminasi presistemik (presystemic metabolism), first pass effect, atau first-pass metabolism, mengacu pada metabolisme obat dalam hati atau usus sebelum mencapai sirkulasi sistemik, yang mengakibatkan konsentrasi obat berkurang secara signifikan.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
3 lis 2023 · The first-pass effect is a pharmacological phenomenon in which a medication undergoes metabolism at a specific location in the body. The first-pass effect decreases the active drug's concentration upon reaching systemic circulation or its site of action.
Fenomena ini disebut sebagai first pass metabolism (metabolisme lintas pertama) yang merupakan faktor utama penentu besar bioavailabllitas obat. Efek dari metabolisme lintas pertama dinyatakan sebagai extraction ratio , yang besarnya dapat ditentukan dengan rumus:
First pass metabolism describes the metabolism of a drug molecules before it reaches the systemic circulation and can also be referred to as pre-systemic metabolism. Although it is possible via other routes of administration, it is predominant in drugs administered orally.
30 lip 2023 · The liver is the site of first-pass metabolism. The bioavailability of a drug will be reduced proportionally to the fraction of the initial dose converted to inactive metabolites by liver enzymes. Notably, hepatic cytochrome P450 metabolism can significantly alter drug bioavailability.
