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19 cze 2021 · In this chapter, we review the etiology and pathogenesis of Type 1 diabetes mellitus (T1DM), with particular emphasis on the most common immune mediated form. Whereas Type 2 diabetes (T2DM) appears to be an increasing price paid for worldwide societal affluence, there is also evidence worldwide of a rising tide of T1DM.
This chapter will review the major types of diabetes and the etiologic factors that are known to or are speculated to contribute to these disorders and present an overview of emerging theories underlying the pathogenesis of type 1 and type 2 diabetes. Expand. View via Publisher. media.wiley.com. Save to LibrarySave. Create AlertAlert. Cite. Share.
In type 1 diabetes, the primary etiology is due to a cellular-mediated autoimmune-mediated destruction of the β cells of the pan-creas. Traditionally, in subjects with type 1 diabetes, autoantibodies may be detected that reflect the underlying attack against these cells [5].
The physiology of diabetes is a complex interplay between pancreatic beta-cell function and insulin resistance. Other hormones such as GLP-1 and leptin also play a role. The classic presentation of type 2 diabetes is polyuria, polydipsia, and unintentional weight loss.
1 wrz 2023 · The etiology of this form of diabetes involves a combination of genetic and environmental factors. The disease is often related to various lifestyle factors such as poor diet, age, lack of exercise, family history of diabetes, obesity, earlier gestational diabetes mellitus in women, and pathophysiological conditions like atherosclerosis ...
1 cze 1984 · The concept that diabetes mellitus is not a single disease. but rather a clinical syndrome characterized by inappropriately elevated fasting or post-prandial blood glucoses and the development of long-term microvascular, macrovascular, and neuropathic changes is of very recent origin and stems from numerous investigations into the epidemiology ...
Evidence emerged suggesting that human diabetes mellitus has a multifactorial etiology, and larger doses of insulin were required to normalize the blood sugar in patients with the milder nonketotic form of the disease common in the older population, whereas smaller doses were adequate for younger, ketosis-prone diabetics.
