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1 maj 2023 · Endochondral ossification begins with mesenchymal tissue transforming into a cartilage intermediate, which is later replaced by bone and forms the remainder of the axial skeleton and the long bones. Bone ossification, or osteogenesis, is the process of bone formation.
Figure 6.4.2 – Endochondral Ossification: Endochondral ossification follows five steps. (a) Mesenchymal cells differentiate into chondrocytes that produce a cartilage model of the future bony skeleton. (b) Blood vessels on the edge of the cartilage model bring osteoblasts that deposit a bony collar.
Endochondral ossification[1][2] is one of the two essential pathways by which bone tissue is produced during fetal development of the mammalian skeletal system, the other pathway being intramembranous ossification.
Endochondral ossification is the process by which the embryonic cartilaginous model of most bones contributes to longitudinal growth and is gradually replaced by bone. During endochondral ossification, chondrocytes proliferate, undergo hypertrophy and die; the cartilage extracellular matrix they con ….
7 sie 2001 · The conversion of this cartilaginous model to bone with accompanying longitudinal growth is called endochondral ossification. This process requires a temporal and spatial balance between extracellular matrix deposition and degradation, chondrocyte proliferation and apoptosis plus vascularisation and mineralisation.
During embryonic development, bone forms by endochondral or intramembranous ossification and can arise from the paraxial and lateral plate mesoderm or neural crest.
