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Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.
Learn about the processes, enzymes, and factors that affect drug metabolism in the liver and other tissues. Find out how drug metabolism influences drug interactions, efficacy, and toxicity.
18 paź 2019 · Drug metabolism is the prominent process in drug disposition. Understanding the metabolic fate and the corresponding enzymes are important with regard to metabolite toxicity and drug–drug interaction risks. Detailed data from drug metabolism studies aid in the drug clinical practice and drug design and modification.
Drug metabolism controls the levels of drugs in the body and may detoxify or activate a drug. In a nutshell, the goals of metabolite isolation and identification include (1) determination of routes of elimination, (2) estimation of rates of metabolic reactions, (3) assessment of metabolic stability, (4) testing of metabolizing enzyme inhibition ...
12 kwi 2018 · Drug metabolism as a discipline plays an important role in drug discovery and development and the effects of drug metabolism on pharmacokinetics (PK), pharmacodynamics (PD), and safety should be carefully considered.
26 lis 2021 · Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis.
1 sty 2022 · Learn about the definition, mechanisms, and classification of drug metabolism, the (bio)chemical modification of a drug by the body. Explore the role of enzymes, organs, and tissues in drug biotransformation and excretion.
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