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The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). The symbol for half-life is t½. For example, if 100mg of a drug with a half-life of 60 minutes is taken, the following is estimated:
20 cze 2023 · The definition of elimination half-life is the length of time required for the concentration of a particular substance (typically a drug) to decrease to half of its starting dose in the body. Understanding the concept of half-life is useful for determining excretion rates as well as steady-state concentrations for any specific drug.
Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma.
Half-life can vary significantly between drugs. Some drugs have a short half-life of only a few hours and must be given multiple times a day, whereas other drugs have half-lives exceeding 12 hours and can be given as a single dose every 24 hours.
30 lip 2023 · The half-life is the amount of time for serum drug concentrations to decrease by 50%. Defined by the equation t=(0.693xVd)/Clearance, a drug's half-life is directly proportional to the volume of distribution and inversely to clearance.
The half-life of a drug helps us assess the potency and toxicity of a drug over a given amount of time. If we know the elimination time, we can easily evaluate how often the drug should be administered to maximize its effect and minimize its adverse reactions.
A drug's half–life is the time required for a drug to reach 50% of steady-state levels during administration or to decay 50% from steady-state levels after administration ceases. From: Comprehensive Clinical Psychology, 1998
