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Learn how drugs are absorbed across cell membranes by different mechanisms, such as passive diffusion, facilitated diffusion, active transport, and pinocytosis. Compare oral, parenteral, and controlled-release forms of drugs and their factors affecting absorption.
- Drug Distribution to Tissues
After equilibrium, drug concentrations in tissues and in...
- Drug Bioavailability
Peak time (when maximum plasma drug concentration occurs) is...
- Drug Metabolism
Hepatic drug transporters are present throughout parenchymal...
- Overview of Pharmacokinetics
Pharmacokinetics, sometimes described as what the body does...
- Jennifer Le
Learn about Jennifer Le — qualifications, affiliations, and...
- Drug Distribution to Tissues
Absorption is the process of a drug moving from its site of delivery into the bloodstream. The chemical composition of a drug, as well as the environment into which a drug is placed, work together to determine the rate and extent of drug absorption.
27 lut 2024 · Understanding the drug absorption process and affecting factors is essential in achieving better bioavailability and therapeutic effects. This article will discuss the different mechanisms of drug absorption, the affecting factors, and their correlation to bioavailability.
Absorption is the journey of a drug travelling from the site of administration to the site of action. [1] [2] The drug travels by some route of administration (oral, topical-dermal, etc.) in a chosen dosage form (e.g., tablets, capsules, or in solution). [3]
Drug absorption is the movement of a drug into the bloodstream after administration. (See also Introduction to Administration and Kinetics of Drugs .) Absorption affects bioavailability—how quickly and how much of a drug reaches its intended target (site) of action.
Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. Dosage forms (eg, tablets, capsules, solutions), consisting of the drug plus other ingredients, are formulated to be given by various routes (eg, oral, buccal, sublingual, rectal, parenteral, topical, inhalational).
Pharmacokinetics describes the processes that underpin how the human body handles a drug. There are four elements to pharmacokinetics: absorption, distribution, metabolism, and excretion. Drug absorption involves the movement of the drug across a cell membrane and is largely dependent on diffusion.
