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1 lut 2016 · Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms. It can also trigger fatal arrhythmias.
- PubMed
2013 ACCF/AHA guideline for the management of heart failure:...
- Digoxin Toxicity
Digoxin exhibits its therapeutic and toxic effects by...
- PubMed
8 sie 2024 · Learn about the symptoms, diagnosis, and treatment of digoxin toxicity, a clinical condition caused by overdose of a cardiac glycoside. Find out the risk factors, investigations, and management options for acute, acute on chronic, or chronic toxicity.
Treatment for digoxin toxicity should be initiated by the first medical contact (e.g. emergency physician, intensive care physician or cardiologist); subsequent care may require input of an interdisciplinary team with expertise in toxicology and intensive care.
Digoxin's narrow therapeutic window and nonspecific signs and symptoms of toxicity create clinical challenges and uncertainty around the diagnostic criteria of toxicity and responsive treatment choices for the bedside clinician.
4 mar 2023 · Digoxin exhibits its therapeutic and toxic effects by poisoning the sodium-potassium ATPase. The subsequent increase in intracellular sodium leads to increased intracellular calcium by decreasing calcium expulsion through the sodium-calcium cation exchanger.
16 kwi 2024 · Learn about the symptoms, diagnosis, and treatment of digoxin overdose, a potentially life-threatening condition caused by excessive intake of digoxin or other cardioactive steroids. Find out how to use digoxin-specific antibody fragments, lidocaine, and phenytoin to manage cardiac dysrhythmias.
1 gru 2023 · The recommendations highlight the importance of early recognition of signs of potentially life-threatening toxicity that requires immediate treatment with digoxin-specific antibodies. The consensus identifies a straightforward approach to dosing immune antibody fragments according to the presence or absence of signs of life-threatening toxicity.
