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13 cze 2005 · The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.
Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. [1] It may also be used for prevention of loiasis in those at high risk. [1]
Dietylokarbamazyna (łac. diethylcarbamazinum) – wielofunkcyjny organiczny związek chemiczny, pochodna piperazyny, stosowana jako ogólnoustrojowy lek przeciwrobaczy. Mechanizm działania dietylokarbamazyny nie jest znany, wiadomo jednak, że wpływa na szlak kwasu arachidonowego [5]. Zastosowanie.
28 lip 2020 · Verma et al. describe a new mechanism for diethylcarbamazine action, a drug classically used to treat lymphatic filariasis and loiasis.
The mechanism of action of diethylcarbamazine is thought to involve sensitizing the microfilariae to phagocytosis. One study showed that diethylcarbamazine's activity against Brugia malayi microfilariae is dependent on inducible nitric-oxide synthase and the cyclooxygenase pathway.
20 mar 2020 · Diethylcarbamazine is a commonly used anti-filarial drug. It has many other pharmacological actions. It is a potent leukotriene inhibitor. Leukotrienes have an important role in mechanism of asthma and allergic rhinitis .
The mechanism of action of diethylcarbamazine involves two processes: • first, filarial muscular activity decreases, probably secondary to hyperpolarization of membranes by the piperazine moiety of diethylcarbamazine; and • second, microfilarial surface membranes are altered by making them more susceptible to host defenses.
