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Studies have shown that when serum vancomycin levels are maintained above 10 mcg/mL, the emergence of vancomycin intermediate-resistant S. aureus and vancomycin-resistant S. aureus are less likely to develop. 2 Consensus guidelines recommend a target trough concentration of 15 to 20 mcg/mL for clinical success in severe infections. 2 To reach ...
6 lut 2021 · This systematic review and meta-analysis identified trough concentrations and AUC values of VCM associated with its effectiveness and safety. Furthermore, compared to trough-guided monitoring, AUC-guided monitoring showed higher potential to reduce the incidence of VCM-induced AKI.
Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin trough...
7 paź 2024 · The Infectious Disease Society of America guidelines recommend vancomycin trough levels of 15–20 mg/L for severe methicillin-resistant Staphylococcus aureus. However, recent consensus guidelines of four infectious disease organizations no longer recommend vancomycin dosing using minimum serum trough concentrations.
However, many guideline organizations recommend a trough vancomycin concentration between 15 - 20 mg/L, particularly for complicated infections such as bacteremia, endocarditis, osteomyelitis, meningitis, and hospital-acquired pneumonia caused by methicillin-resistant S. aureus, with a minimum trough level of 10 mg/L in order to avoid developmen...
14 paź 2020 · Our study found that achieving an initial therapeutic vancomycin trough level in critically ill patients with gram positive infection was associated with older age, female gender, loading dose, bacteremia, high platelets count, low estimated glomerular filtration rate, and low albumin level.
24 lis 2021 · A retrospective cohort study was conducted for all adult critically ill patients with confirmed Gram-positive infection who received IV vancomycin between January 1, 2017, and December 31, 2020. We compared early (< 48 h) versus late (≥ 48 h) attainment of vancomycin therapeutic trough levels.
