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Upper endoscopy is the appropriate test for evaluating dysphagia, identifying evidence of GERD, such as esophagitis, and identifying possible reflux complications, such as esophageal stenosis, Barrett’s esophagus and esophageal adenocarcinoma.
Barrett’s esophagus and esophageal adenocarcinoma. Reflux-related disorders such as SSc are naturally conducive to the development of Barrett’s esophagus. Pathophysiology of Barrett’s esophagus is tied to increased acidic insult of esophageal epithelium.
16 mar 2011 · Barrett’s oesophagus (BE) is the major risk factor for oesophageal adenocarcinoma (EAC). SSc is associated with an increased risk of BE related to chronic reflux. The aim of this study is to determine the outcomes of BE and estimate the EAC risk in SSc patients over a 3-year prospective study.
1 mar 2021 · Women with SSc with BE were significantly more likely to have scleroderma esophagus (absent contractility with hypotensive lower esophageal sphincter) on HRM than women with SSc without BE (P = 0.018). There were 30 patients with SSc (12.8%) with histologically proven BE.
Objective: Barrett's oesophagus (BE) is the major risk factor for oesophageal adenocarcinoma (EAC). SSc is associated with an increased risk of BE related to chronic reflux.
Some patients with SSc and chronic GERD develop Barrett's esophagus (BE), a change of the normal squamous epithelium of the distal esophagus to a columnar-lined intestinal metaplasia. BE, which can progress to dysplasia, is a known risk factor for esophageal adenocarcinoma.
Scleroderma mainly affects women, whereas Barrett’s esophagus (BE) predominantly affects men. The reported prevalence of BE in women with scleroderma varies widely from 6% to 37%, and is mainly derived from older small studies.
