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Zonisamide may be associated with the following side effects in dogs: sedation; incoordination while walking; vomiting; lack of appetite; Contact your veterinarian if these signs are severe. Rare side effects in dogs include: liver disease; urinary stones ; aggression
28 paź 2021 · MRI study and cerebrospinal fluid analysis in two dogs were unremarkable. The abnormal behavior episodes deteriorated along with gradual dose increment of zonisamide and these episodes almost completely disappeared within 5 days after discontinuation of zonisamide.
22 lut 2016 · The therapeutic target range for zonisamide of 10–40 μg/mL in people can be used as guidance regarding effective concentrations that can be targeted in dogs. Serum zonisamide concentration should be monitored 1–2 weeks after treatment initiation or dosage adjustment and any time seizure frequency increases.
28 sie 2015 · Thus, zonisamide should be used with caution in dogs with renal or hepatic impairment. Both, hepatic and renal failures have been described in humans receiving zonisamide as well. Currently, zonisamide is not available in every country and when available, it can be very expensive.
23 maj 2024 · Currently, ZNS is not approved for use in dogs or cats in either the United States or Europe and is typically employed as a 2nd- or 3rd-line option. To date, information on the clinical efficacy of ZNS as a treatment for epilepsy is limited in veterinary medicine.
1 wrz 2004 · In a recent study, zonisamide decreased seizure frequency by at least 50% in seven of 12 dogs with refractory idiopathic epilepsy. In this responder group, the mean reduction in seizure frequency was 81.3%.
8 sty 2022 · Zonisamide is an anticonvulsant medication unrelated to other anticonvulsants routinely used for treating dogs and cats. Zonisamide can be used alone or in combination with phenobarbital and/or potassium bromide. This is useful when your pet's seizures are inadequately controlled with those drugs.
