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20 sie 2019 · Passaging of ZIKV PA259249 in HeLa cells led to in vitro attenuation. ZIKV strain PA259249 (a) or FSS13025 (b) was serially passaged in HeLa cells up to six times (P6), and stocks were titrated in Vero cells.
20 sie 2019 · A human isolate from the recent ZIKV epidemic was subjected to serial HeLa cell passaging, resulting in attenuated in vitro replication in both Vero and A549 cells.
20 sie 2019 · Previous studies have shown that mosquito-transmitted flaviviruses, including yellow fever, Japanese encephalitis, and West Nile viruses, could be attenuated by serial passaging in human HeLa...
12 mar 2018 · We identify a ZIKV variant that produces small plaques due to interferon (IFN)-restricted viral propagation and displays attenuated infection of endothelial cells.
15 lip 2024 · We show that inhibition of the host TRPC4 channel or CaMKII impedes ZIKV propagation in human brain organoids and improves survival in a neonatal mouse model of ZIKV infection. ZIKV upregulates the expression of TRPC4 in host cells through the NS3-CaMKII-CREB pathway.
29 lip 2022 · In this study, we demonstrate that exposing ZIKV to human vaginal epithelial cells (hVECs) resulted in de novo viral RNA replication, increased envelope viral protein production, and a steady, extracellular release of infectious viral particles.
4 mar 2022 · Azathioprine-derived thiopurine nucleoside analog, 6-methymercaptopurine riboside (6MMPr) was tested on epithelial and human neuronal cells, revealing efficient, dose-dependent inhibition of ZIKV infection, and lower cytotoxicity for neuronal cells (de Carvalho et al., 2017).
