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1 kwi 2019 · A single mutation in prM (serine to asparagine substitution at position 139) has been associated with the ability of ZIKV to infect cells (Yuan et al., 2017), suggesting that prM could also act as an entry receptor.
20 sie 2019 · Zika virus (ZIKV) is a mosquito-borne Flavivirus. Previous studies have shown that mosquito-transmitted flaviviruses, including yellow fever, Japanese encephalitis, and West Nile viruses, could be attenuated by serial passaging in human HeLa cells. Therefore, it was hypothesized that wild-type ZIKV would also be attenuated after HeLa cell ...
30 sie 2018 · ZIKV is transmitted in an epidemic cycle between Aedes mosquitoes and humans. ZIKV can also be transmitted through sexual contact or vertical transmission from an infected pregnant mother to her...
4 mar 2022 · As ZIKV invade neuronal cells, they trigger neurotoxic mechanisms via cell-autonomous and non-cell autonomous pathways, resulting in neurogenesis dysfunction, viral replication, and cell death, all of which eventually lead to microcephaly.
20 sie 2019 · A human isolate from the recent ZIKV epidemic was subjected to serial HeLa cell passaging, resulting in attenuated in vitro replication in both Vero and A549 cells.
10 mar 2022 · ZIKV adsorbs to the cell surface receptor AXL to enter CNS cells. When the viral replication machinery is active, ZIKV produces non-structural proteins (NS). The NS2B and NS3 help to inhibit antiviral response by regulating type 1 IFN pathways.
15 maj 2020 · To characterize immune responses to ZIKV, here we examine transcriptional signatures of CD4 T, CD8 T, B, and NK cells, monocytes, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells...
