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ZIKV also targets cells of the reproductive tract, including spermatogonia, Sertoli cells, and Leydig cells (in the testis of mice), sperm (samples from mice and humans), and the vaginal epithelium (mice) and uterine fibroblasts (in vitro infection of human samples).
1 kwi 2019 · Zika virus (ZIKV) is an enveloped, mosquito-borne Flavivirus, which infects cells through clathrin-mediated endocytosis and fusion employing acidic endosomes.
20 sie 2019 · Zika virus (ZIKV) is a mosquito-borne Flavivirus. Previous studies have shown that mosquito-transmitted flaviviruses, including yellow fever, Japanese encephalitis, and West Nile viruses, could be attenuated by serial passaging in human HeLa cells.
20 sie 2019 · Zika virus (ZIKV) is a mosquito-borne Flavivirus. Previous studies have shown that mosquito-transmitted flaviviruses, including yellow fever, Japanese encephalitis, and West Nile viruses, could...
15 lip 2024 · We show that inhibition of the host TRPC4 channel or CaMKII impedes ZIKV propagation in human brain organoids and improves survival in a neonatal mouse model of ZIKV infection. ZIKV upregulates the expression of TRPC4 in host cells through the NS3-CaMKII-CREB pathway.
ZIKV replication leads to activation of an antiviral innate immune response and the production of type I interferons in infected cells. Taken together, these results provide the first general insights into the interaction between ZIKV and its mammalian host.
29 lip 2022 · To determine if ZIKV induces cytopathic effects (CPEs) in the human vaginal epithelium, we exposed VK2 cells to ZIKV and later monitored characteristics of virus-induced cytotoxicity using light microscopy.
