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Although disturbances of mood, cognition, sleep, and behavior as well as frank delirium or even psychosis are possible, the most common adverse effects of short-term corticosteroid therapy are euphoria and hypomania. Conversely, long-term therapy tends to induce depressive symptoms.
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The mechanism by which the corticosteroid induces symptoms such as mania, depression, and psychosis is not clear. The administration of prednisone is associated with decreased levels of corticotrophin, norepinephrine, and beta-endorphin in the cerebrospinal fluid.
26 maj 2020 · Steroid-induced psychosis manifest mild to severe symptoms, ranging from anxiety, insomnia, and irritability to mania, psychosis, delirium, and depression, among others.
24 sie 2021 · Especially when taken for long periods of time, tablets have much more severe side effects than creams do, for instance. This is because the steroids go from the stomach into the bloodstream, and then spread throughout the rest of the body.
1 paź 2014 · An illustrative case vignette is presented describing a patient’s experience of cycles of manic-like behavior and depression while on high-dosage prednisone, with long-term cognitive disorganization, vulnerability to stress, and personality changes.
In this study, the corticosteroid-treated group had significantly higher scores on the Beck Depression Inventory and Brief Symptom Inventory (p < .01) than the controls. These findings could suggest an increase in depressive symptoms with steroids. However, this study did not use measures for mania.
Advances are being made in understanding the fundamental biology of a spectrum of neuropsychiatric disorders including dementias such as Alzheimer’s disease, major mood disorders, schizophrenia, anxiety disorders, alcoholism, and drug dependence.
