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Unopposed estrogens occur when progestogen levels do not balance estrogens, primarily deriving from overproduction of estrogens via aromatase enzyme. In the endometrium, unopposed estrogens induce proliferative or invasive phenomena, which represent the first step toward different diseases.
Un-opposed estrogens occur when progestogen lev-els do not balance estrogens, primarily deriving from overproduction of estrogens via aromatase enzyme. In the endometrium, unopposed estro-gens induce proliferative or invasive phenomena, which represent the first step toward different dis-eases.
Unopposed estrogens occur when progestogen levels do not balance estrogens, primarily deriving from overproduction of estrogens via aromatase enzyme. In the endometrium, unopposed estrogens induce proliferative or invasive phenomena, which represent the first step toward different diseases.
15 sie 2012 · Unopposed estrogens include conjugated equine estrogen (CEE), ethinyl estradiol (EE), micronised 17β‐estradiol (E2), estradiol valerate (EV), estrone sulphate (EIS) and esterified estrogens (ESE). These estrogens cannot be considered equal.
Key points: Unopposed estrogen replacement is associated with a significant increase in the risk of endometrial hyperplasia that is both dose and duration dependent with exposure between one and three years.
1 lis 2012 · Unopposed estrogen therapy has been associated with the development of endometrial cancer, and therefore a progestational agent should be added to prevent hyperplasia and endometrial cancer.
27 lis 2021 · It is well established that unopposed estrogen, either endogenous or therapeutic, can induce endometrial hyperplasia and potentially endometrial cancer (EC). Anovulatory cycles,...
