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10 wrz 2024 · Under every cancer is a cell lineage tree describing the relationships and history of the cells within the cancer 74,171. Defining clones is a matter of dividing up that evolutionary tree...
Cancer cells, both within and between tumours, can have distinct cellular morphologies, gene expression patterns, proliferation rates, metastatic potential and sensitivity to treatment.
1 lis 2023 · Cancer is a group of diseases characterized by the uncontrolled proliferation of cells. Ignoring the body's signal to stop, malignant cells multiply to form tumors in organs and tissues or, in the case of blood cancers, crowd out normal cells in the blood stream and bone marrow.
Early observations of cancer cells grown in culture revealed that, unlike normal cells, cancer cells can proliferate indefinitely. Scientists have recently discovered the molecular basis for this characteristic—an enzyme called telomerase, that systematically replaces telomeric segments that are trimmed away during each round of cell division.
21 paź 2023 · Unlike normal cells that remain in the region where they began, cancer cells have the ability to both invade nearby tissues and spread to distant regions of the body. This article discusses cancer cells. It explains how cancer cells develop and how they differ from normal cells.
A better understanding of the cause (s) of the origin of cancer led to its definition as a genetic disease at the somatic level and heralded a new era for molecular diagnosis and the development of more mechanistic evidence-based, targeted cancer therapies.
Cancer cells typically display abnormalities in the mechanisms that regulate normal cell proliferation, differentiation, and survival. Taken together, these characteristic properties of cancer cells provide a description of malignancy at the cellular level.
