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It is well known that chronic alcoholics are at high risk for being deficient in vitamin B1 (thiamine), which is known to put the patient at an increased risk for Wernicke-Korsakoff Syndrome, cerebellar degeneration, and cardiovascular dysfunction.
Oral thiamine is ineffective in thiamine deficiency and should not be used in the initial treatment phase. The preferred route of thiamine ad ministration is intravenous (IV), although intramuscular (IMI) route is acceptable if IV access cannot be obtained or continued.
3 lis 2021 · Thiamine deficiency can be treated by stopping alcohol consumption, eating a nutritious diet and by taking vitamin B1 supplements. 1 However, diet and supplements alone are not effective if heavy alcohol use continues because alcohol will block absorption.
1 mar 2020 · Given the potential benefit of preventing thiamine deficiency, oral thiamine supplementation is a consideration in the office management of alcohol use disorders and alcohol withdrawal.
3 gru 2018 · It includes screening all alcohol-use patients for Wernicke encephalopathy and administering IV thiamine within the 72-hour window to all who exhibit at least one of the three indicators or who are too intoxicated to be screened.
18 lis 2004 · Specifically, the prophylactic treatment for at-risk patients consists of an intramuscular administration of 250 mg thiamine (plus other B vitamins and ascorbic acid), once daily for 3–5 consecutive days.
Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated.
