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WE is a neuropsychiatric complication caused by thiamine (vitamin B1) deficiency, which is characterised by a triad of symptoms: • Confusion • Ataxia (muscle incoordination) • Ophthalmoplegia (paralysis of the ocular muscles) WE often occurs in people with chronic alcohol dependence, with detox being a major risk factor.
Wernicke-Korsakoff syndrome (WKS) is a disorder of the brain caused by a deficiency of vitamin B 1 (thiamine). It is characterised by an acute onset of some or all of an eye movement disorder, lack of voluntary coordination of muscle movement (ataxia) and confusion.
It is well known that chronic alcoholics are at high risk for being deficient in vitamin B1 (thiamine), which is known to put the patient at an increased risk for Wernicke-Korsakoff Syndrome, cerebellar degeneration, and cardiovascular dysfunction.
1 mar 2020 · In the management of patients with alcohol dependence, physicians should have a high index of suspicion for thiamine-deficient states, especially Wernicke-Korsakoff syndrome.
Two randomised controlled trials examined differences in cognitive or neurological response to varied thiamine dose regimens for 1) treatment of acute Wernicke Korsakoff’s Syndrome and 2) the prevention of WKS in asymptomatic but at-risk patients.
6 cze 2024 · Intramuscular and intravenous thiamine can be used to prevent complications of alcohol dependence such as Wernicke’s encephalopathy.
18 lis 2004 · Specifically, the prophylactic treatment for at-risk patients consists of an intramuscular administration of 250 mg thiamine (plus other B vitamins and ascorbic acid), once daily for 3–5 consecutive days.
