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18 mar 2023 · Short Summary: Thiamine deficiency is a frequent condition in patients with alcohol use disorder and associated with cognitive decline and dementia. Two thiamine substitution regimens were evaluated and increases in thiamine levels were associated with pronounced improvements of cognitive function.
1 mar 2020 · In the management of patients with alcohol dependence, physicians should have a high index of suspicion for thiamine-deficient states, especially Wernicke-Korsakoff syndrome. Given the potential benefit of preventing thiamine deficiency, oral thiamine supplementation is a consideration in the office management of alcohol use disorders and ...
12 kwi 2011 · MRI should be used to support the diagnosis of acute WE in patients both with and without alcoholism. Thiamine is indicated for the treatment of suspected or manifest WE, and should be ...
15 kwi 2022 · Two double-blind, parallel groups, randomized controlled trials (RCTs) were conducted to determine the optimal thiamine dose required for (1) the prevention of Wernicke's encephalopathy (WE), the acute phase of WKS, in asymptomatic but “at-risk” alcohol misuse patients (Study 1) and (2) the treatment of WE in symptomatic alcohol misuse patients ...
Oral thiamine is ineffective in thiamine deficiency and should not be used in the initial treatment phase. The preferred route of thiamine administration is intravenous (IV), although intramuscular (IMI) route is acceptable if IV access cannot be obtained or continued.
20 mar 2023 · Aims: While clinical consequences of thiamine deficiency in alcohol use disorder (AUD) are severe, evidence-based recommendations on dosage, type of administration and duration of thiamine...
Thiamine deficiency (vitamin B1) is common in patients with alcohol dependence. Cognitive impairments may be an early consequence of thiamine deficiency. Wernicke's encephalopathy is underdiagnosed and undertreated.
